Correlation Expression of Autophagy Marker LC3B with Histopathological Grading and Molecular Subtypes in Invasive Breast Carcinoma of No Special Type

Background: Breast cancer is one of the cancers with highest incidence in women. Invasive breast carcinoma found most and infiltrates tissues. LC3B a marker autophagy an important protein involved formation autophagosomes. The acts as tumor suppressor. Therefore, lack LC3 expression has been reported to be associated survival high mortality rates TNBC. Objective: To analyze correlation histopathological grading molecular subtypes invasive no special type (IBC-NST). Methods: This study was analytic cross sectional approach on 40 samples paraffin block diagnosed IBC-NST. Slides were made routine staining hematoxyllin eosin immunohistochemistry LC3B. expressed cytoplasm cells. Scores for based multiplication proportion intensity staining. Correlation IBC-NST statistically tested. Results: Most patients occur age 40-49 years, average 50,1 youngest 27 years oldest 73 years. size according T2 criteria. luminal. grade 3. Immunohistochemical strong expression. Conclusions: showed significant between immunohistochemical (p-value 0.0001). There subtype <0.05). role suppressor, by inducing effective therapeutic strategy especially